Groundbreaking Study Identifies Genetic Mutation Linked to Hearing Loss, Offers New Prevention Strategy
Researchers at the University of California San Francisco (UCSF) have made a groundbreaking discovery that a genetic mutation responsible for a type of hearing loss operates similarly to the mechanisms involved in noise-induced and age-related hearing loss. This finding suggests that blocking this pathway could protect ears from damage and potentially prevent deafness. The UCSF team identified mutations in the Tmtc4 gene that trigger the unfolded protein response (UPR), a cellular process that typically helps manage misfolded proteins but can lead...